Hi Uwe,
Sorry to hear of the problems, I'm sure there will be others along later to chip in with suggestions. For now though....
A single high resistance could indicate a problem, assuming you're using suppressed leads rather than the older copper wire with suppressed spark plug caps, but it depends on the actual numbers because on one of my sets they all vary slightly despite logic saying they should be the same. The exhausts will transfer some heat to the adjacent ones by conduction, I think you'd need an accurate measurement on individual outlets to determine a faulty cylinder using the exhaust gas temperatures alone.
My first thoughts with any irregular running is to to remove and inspect the 4 spark plugs to see if they are all identical or if one is black/oily/sooty/basically not right
Hopefully you will find the plug fed by your high resistance lead to be black with all the others a light sandy brown, in which case a new set of leads would be on the list of options. But also check the plug connection/lead connection to the distributor cap and finally the internals of the distributor cap for damage/erosion on that current feed post.
After that it's just a case of going through a system check list. Assuming you have the OEM points/condensor/coil then apart from checking that the wiring circuit shows no signs of broken/loose wires & all have clean connections I'm ashamed to say my approach is to simply replace things one at a time.
Yep, it's not scientific and is more expensive, but all the parts are available and relatively cheap. Assuming the plugs are new, my order is usually points/condenser together and if that doesn't work then the coil as last option. The distributor cap & rotor arm can be checked visually when replacing the points and any faults are usually obvious, for example there have been cases of some rotor arms which have a riveted arm shorting to earth with the rivet loosening, damage to the central carbon brush in the distributor cap and erosion of terminal posts is easy to spot when it's all apart, etc.
Brian